In general, standard hydrolysed collagen peptides are produced by breaking collagen tissue into a broad mixture of peptides with different molecular sizes and amino acid sequences. Although they provide collagen-derived amino acids, they may not contain identified or guaranteed amounts of specific bioactive peptides. Therefore, molecular weight alone does not determine efficacy; the peptide sequence and its concentration are equally important.

Collagen is specifically distinguished by three(3) anchor amino acids—glycine, proline and hydroxyproline—which form and stabilise its characteristic structure:

• Glycine: Enables the collagen chains to pack tightly together.
• Proline: Supports the shape and rigidity of the collagen structure.
• Hydroxyproline: Helps stabilise the collagen triple helix.

The value of a collagen ingredient therefore depends not only on supplying these amino acids, but also on delivering them in specific peptide sequences capable of supporting biological activity.

This is where Wellnex® Di-Peptide Type S is differentiated. It is standardised to contain defined levels of two clinically studied bioactive dipeptides:

• Pro-Hyp (OP): Stimulates fibroblasts to produce new collagen.
• Hyp-Gly (OG): Supports the formation and maintenance of the collagen network.

Together, PO and OG incorporate all three collagen anchor amino acids and provide complementary mechanisms that support collagen synthesis and the health of the skin, joints and connective tissues.

Another key advantage is that Wellnex® Di-Peptide Type S is effective at half the daily dose compared with standard hydrolysed collagen peptides:

In addition to these functional advantages, Wellnex® Di-Peptide Type S also offers a less fishy taste, providing a more pleasant consumption experience.

Therefore, the advantage of Wellnex® Di-Peptide Type S lies in its known PO/OG composition, targeted biological activity, and efficacy at a lower daily dose—not merely its smaller peptide size.

Similarly, promoting collagen tripeptides without declaring and guaranteeing the amount of the relevant POG (Pro-Hyp-Gly) sequence present is simply a marketing gimmick rather than evidence of superior efficacy.

What is Wellnex® Di-Peptide Type S?

is a premium collagen peptide developed by Nitta Gelatin. It is enriched with highly bioactive collagen dipeptides—Prolyl-Hydroxyproline (Pro-Hyp) and Hydroxyprolyl-Glycine (Hyp-Gly)—which are rapidly absorbed and help stimulate collagen-producing cells.

With a low molecular weight (≤1,000 Da) and a high concentration of functional dipeptides (≥40%), Wellnex® delivers superior bioavailability and efficacy at lower dosages than conventional collagen peptides.

Clinical studies have demonstrated benefits for skin hydration, elasticity, wrinkle reduction, visible pigmentation, joint health, wound healing, and healthy aging by reducing advanced glycation end products (AGEs).

Contact us to know more about Wellnex Dipeptide Type-S.